ea0013p204 | Endocrine tumours and neoplasia | SFEBES2007
Patel Mayur
, Symonds Dawn
, Jonas Kim
, Vaisse Christian
, Korbonits Marta
, Fowkes Rob
Hypothalamic MC4R receptors are Galphas-coupled GPCRs that mediate the satiety response to αMSH. MC4R expression predominates in the PVN/VMH regions of the hypothalamus, regulating satiety gene expression (e.g. Bdnf). Human MC4R mutations often result in compromised Galphas-cAMP-PKA signalling and obesity onset. However, downstream signalling pathways have yet to be elucidated. We have investigated the potential for αMSH to stimulat...